Featured in Engineering at Maryland: Built for Breakthrough

In the latest issue of Engineering at Maryland: Built for Breakthrough, Amal Shabazz and Lexi Christensen are acknowledged for their work in advancing breast reconstruction. See below for the entire story:

More than 100,000 women undergo mastectomies each year to treat or prevent breast cancer. Though the procedure can be lifesaving, its emotional toll can be devastating: More than two-thirds of patients say the changes in their bodies led them to experience significant psychological distress. While breast reconstruction can help, the process is incomplete at best, in part because there are few methods to effectively recreate the pigmented area of the breast known as the nipple-areolar complex (NAC). Many women feel that tattoos, a common solution, are a far from perfect replacement. That may soon change, thanks to efforts led by graduate students Lexi Christensen and Amal Shabazz, who work in John Fisher’s laboratory within the Fischell Department of Bioengineering. Christensen, Shabazz, and Fisher have developed a promising 3D-printed NAC that pairs non-degradable materials to support the NAC’s shape and mechanical properties with degradable biomaterials that support the growth of connective tissue and blood vessels within the implant. The work offers a level of sophistication that was all but impossible to create previously, says Fisher. “3D printing can precisely assemble many materials and many cell types into an object in ways that can’t be replicated by other processes,” he says. “We can use printing to build tissues that approach the complexity of our own tissues.” Their efforts are gaining momentum: After securing initial support from an NIH grant, Fisher and his team are partnering with a local Maryland company to help build implants ready for FDA approval—and patient use—before 2030.

The story was adapted from the Engineering at Maryland Fall/Winter 2024 issue.

BIOE Ph.D. Student Elected to BMES Board of Directors

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Bioengineering Ph.D. student Amal Shabazz was recently elected as a Student Representative to the Biomedical Engineering Society (BMES) Board of Directors.

Shabazz is a graduate researcher in the Tissue Engineering & Biomaterials Lab (TEBL), led by Fischell Department of Bioengineering (BIOE) Chair and Distinguished Professor John P. Fisher. In the lab, Shabazz works to 3D print tissue and implants for breast cancer patients. An active student, NSF GRFP fellow, researcher, and advocate, Shabazz is excited to join the BMES Board of Directors to amplify the voices of students and promote ideas that support underrepresented groups in biomedical engineering.

Shabazz’s journey into biomedical engineering began from birth, inspired by her mother’s development of Rh-incompatibility, a potentially life-threatening condition that causes the immune system to attack the fetus’ red blood cells during pregnancy. She enrolled at the New Jersey Institute of Technology (NJIT) with the intention of understanding the function of the body and the role of the immune system in recognizing and responding to foreign substances. As she progressed into more specialized classes in tissue engineering during her junior and senior years, her interest and comfort with the material grew. Shabazz was particularly drawn to tissue engineering as it aligned with her goal of directly impacting the lives of underrepresented patients through innovative medical solutions.

During her undergraduate years, Shabazz joined a research lab focused on tissue engineering, where she worked on projects related to osteochondral and neural tissue engineering. This hands-on experience solidified her desire to pursue a Ph.D., where she could have greater autonomy and contribute meaningfully to research projects.

Shabazz’s decision to pursue a Ph.D. was influenced by mentors like her undergrad research advisor, Dr. Treena Livingston Arinzeh, a trailblazer, accomplished researcher, and professor in biomedical engineering who inspired Shabazz. “I think a lot of what held me back—and what pulls other people back—is not having the experience of working with somebody that looks like them in the field, which makes them feel like their goals are unattainable,” Shabazz explains. “I think that having an opportunity to work with somebody like Dr. Arinzeh was very inspirational for me.”

Dr. Fisher—Shabazz’s current Ph.D. research advisor at UMD—recommended her for the BMES Board of Directors election. He highlighted her dedication, leadership, and passion for addressing health disparities through her research in tissue engineering and regenerative medicine. He emphasizes Shabazz’s commitment to advancing underrepresented students in STEM fields and her proactive involvement in promoting diversity and inclusion within the bioengineering department, where she is a member of the BIOE Diversity, Equity, & Inclusion Committee.

“From the first time I spoke to her during the graduate school interview process, she expressed her curiosity by asking thought-provoking questions about my research and about how she could lead the UMD bioengineering community,” Fisher says. “I quickly recognized her unwavering inclination toward learning and her genuine interest in working toward the creation of life-changing medical solutions.”

In addition to her academic journey, Shabazz was actively involved in organizations like the National Society of Black Engineers (NSBE) as an Academic Excellence Chairperson and the Black Student Union (BSU) as the Vice President during her undergraduate years. These experiences provided her with a supportive community and leadership opportunities that strengthened her skills academically and personally.

Shabazz’s current research at UMD focuses on 3D printing nipple-areola complexes for breast cancer patients who have undergone mastectomy surgeries. Her project aims to develop a functionalized implant that can integrate with host tissue and maintain projection over time, offering an alternative to current surgical approaches.

Looking ahead, Shabazz envisions using tissue engineering and regenerative medicine to address healthcare disparities in minority communities. She aims to develop therapies that are accessible and effective across diverse populations, emphasizing the importance of representation and inclusivity in biomedical research.

Congrats, Amal!

Story adapted from the Fischell Department of Bioengineering.

End of Year Lab Celebration

Before the start of Thanksgiving break, the lab decided to have a fun lunch at Looneys to celebrate all the hard work that has been accomplish this semester. This also gave our new rotational grad student a chance to get to know other members of the lab. Overall, it was a fantastic opportunity to catch up with one another and commemorate the closing of an amazing year in lab.

John P. Fisher Elected Chair of the Council of Chairs

Announced on October 11, 2023 at the Biomedical Engineering Society (BMES) Annual Meeting in Seattle, WA, John P. Fisher, Chair of the Fischell Department of Bioengineering (BIOE) at the University of Maryland, has been named Chair of the Council of Chairs for 2025.

The Council of Chairs (CoC) is a national assembly of more than 150 bioengineering and biomedical engineering department chairs. Supported by BMES, the Council meets throughout the year to help guide bioengineering and biomedical engineering academic units across the country as well as the biomedical engineering field as a whole.

Recently elected to the BMES Board of Directors, Fisher has been a long-time, active member of the Society since 2003. He has served in various roles, including abstract reviewer, session chair, and track chair in numerous Annual BMES Meetings. In 2016, Fisher was named a Fellow of BMES, and in 2018, he was Co-Chair of the BMES Annual Meeting in Atlanta, Georgia, spearheading the large celebration of the BMES 50th Anniversary.

Established in 1968, BMES is the world’s leading professional society for students, faculty, researchers, and industry professionals in biomedical engineering. With over 6,800 members, the society is committed to fostering an inclusive community to advance human health through education, discovery, and translation.

Now serving both on the BMES Board of Directors and as a leader among the Council of Chairs, Fisher is looking forward to guiding positive impact among the biomedical engineering community.

Key initiatives I would like to bring with me to the CoC include reducing financial barriers to education and research; encouraging mentorship; and expanding opportunities for positively impacting our broader communities.

John P. Fisher

“With the Council of Chairs, I aim to address the health, equity, and economic challenges experienced in our communities today,” says Fisher, who is MPower Professor, Distinguished-Scholar Teacher, and Fischell Family Distinguished Professor at UMD. He is also Director of the Tissue Engineering and Biomaterials Lab at UMD, where he leads his research team in investigating biomaterials, stem cells, bioprinting, and bioreactors for the regeneration of lost tissues.

“Historically, I have advocated for enhanced support for students and young investigators in biomedical engineering. Key initiatives I would like to bring with me to the CoC include reducing financial barriers to education and research; encouraging mentorship; and expanding opportunities for positively impacting our broader communities.”

Fisher currently serves as Past-President of the Americas Chapter of TERMIS and was the Co-Chair of the 2014 TERMIS-Americas Annual Meeting. In his TERMIS leadership roles, Fisher led efforts to broaden the TERMIS-Americas Chapter from North America to the entire Americas, established the Diversity, Equity, and Inclusion (DEI) Committee within the chapter, and participated in a delegation to South Africa to launch Africa’s first tissue engineering society.

In addition, Dr. Fisher currently serves as the Co-Editor-in-Chief of the journal Tissue Engineering while serving on the editorial boards of key biomedical engineering journals such as the Journal of Biomedical Materials Research Part ABioprintingBiofabrication; and the Journal of Tissue Engineering & Regenerative Medicine.

Fisher will serve as Chair-Elect on the CoC during 2024 before beginning his term as Chair in 2025.

Story Provided by the Fischell Department of Bioengineering.

Extrusion-based Bioink Printability Paper Receives Top Cited Award

As a part of the Center for Engineering Complex Tissues (CECT) partnership with Wake Forest and Rice University, the paper Assessment methodologies for extrusion-based bioink printability, published in Biofabrication, has earned an IOP Publishing Top Cited Paper Award!

This noteworthy achievement signifies that this research is featured in the top 1% of the most cited papers in the subject category. It is also one of the most cited articles from North America, published across the entire IOP Publishing journal portfolio within the past three years.

Congratulations to everyone involved!