Visiting Materic Manufacturing

On September 29th, a few of the graduate and undergraduate students from the lab had the chance to visit Materic in Balitmore, MD. The lab is collaborating with Materic to work towards the development of GMP grade nipple-areolar complexs (NACs) for Amal’s project. During the visit, the group was able to tour the site, look at some of the 3D printers and other fabrication devices, and visit the GMP facility where sterile prints are produced. Materic’s facility houses a full suite of SLS, SLA, FDM, and DLP 3D printing technologies.

From left to right: Winston Frazier from Materic, Lauren Gomes, Allison Moses, Ryan Felix, Pieper Holeman, Shannon McLoughlin, and Amal Shabazz
Stereolithography (SLA) uses resin 3D printing for highly detailed prototypes requiring tight tolerances and smooth surfaces, such as scaffolds for the NAC.

For some context on Amal’s project – the nipple-areolar complex (NAC) is the structure on the chest that is composed of the nipple and areola. Breast tissue is lost when breast cancer patients undergo a mastectomy to remove cancerous tissue from the breast. Restoration of this tissue is meant to improve patient satisfaction and boost the long term psychological health of these patients. Materic is using stereolithography to fabricate the more rigid part of the scaffold that is meant to provide the mechanical strength needed to maintain the NAC scaffold long term. Extrusion bioprinting will be used to fabricate the softer part of the tissue that is meant to integrate with the body.

Robert Choe Successfully Defends Dissertation and Earns PhD

These past few months, Robert Choe has been working hard to prepare for his dissertation defense. A defense is the last step any graduate student needs to complete to PhD. This is where they present the work they have done over the past five years and show how they completed their thesis in front of a committee of professors. The PhD candidate must “defend” their work to the committee to prove they made a significant difference in their field.

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On Wednesday October 4th, Robert successfully presented his dissertation defense and was awarded his PhD! Robert’s work focused on the development of an implantable osteochondral scaffold for cartilage engineering. Robert leveraged the unique capabilities of 3D printing to build computational models of a broad range of osteochondral scaffolds, identifying the critical parameters that support a strong and resilient bone – cartilage interface. Robert then examined the proper cell delivery strategy for the bone phase of the 3D printed scaffolds, defining a strategy for osteoblast – osteoclast coculture for bone tissue development and maintenance. Robert’s work has already been communicated in 5 journal articles and numerous conference presentations. After BIOE, Robert will return to his DMD roots to take an associate prosthodontist position at ClearChoice Dental Implant Centers. Congratulations again to Robert on both his outstanding work and incredible efforts!

John P. Fisher Elected to BMES Board of Directors

Congratulations to Dr. Fisher as The Biomedical Engineering Society (BMES) announced his election to its Board of Directors beginning this fall. Fisher is a MPower Professor, Distinguished-Scholar Teacher, Fischell Family Distinguished Professor, and Department Chair in the Fischell Department of Bioengineering (BIOE) at the University of Maryland (UMD).

Fisher has been an active member of BMES for more than 20 years, having joined the society in 2003 and been named a Fellow of BMES in 2016. He has served in various roles in the society, including abstract reviewer, session chair, and track chair in numerous Annual BMES Meetings.

“I am thrilled to continue supporting BMES as a member of the BMES Board of Directors and to give back to the society that has provided us with so many opportunities over the years.”

John P. Fisher

Established in 1968, BMES is the world’s leading professional society for students, faculty, researchers, and industry professionals in biomedical engineering. With over 6,800 members, the society is committed to fostering an inclusive community to advance human health through education, discovery, and translation.

BMES hosts an Annual Meeting that brings together over five thousand biomedical engineers each year and puts on more than 2,500 scientific presentations, including talks on cancer treatment, heart disease, women’s health, global health disparities, and more.

In 2018, Fisher was the Co-Chair of the BMES Annual Meeting in Atlanta, Georgia, spearheading the large celebration of theBMES 50th Anniversary.

In addition to his work with BMES, Fisher has served in numerous member and leadership positions within partner societies, including the American Institute for Medical and Biological Engineering (AIMBE); the International Academy of Medical and Biological Engineering (IAMBE); the International Society for Biofabrication (ISBF); the Society for Biomaterials (SFB); and the Tissue Engineering and Regenerative Medicine International Society (TERMIS).

In many of his society positions, as well as in his role at UMD, Fisher has worked closely with historically underserved and underrepresented students, encouraging their participation in and passion for STEM careers.

“Recent events in our country and across the world have presented a number of challenges to our society and within our scientific communities—challenges around health, equity, and economics,” says Fisher.

In his new role on the BMES Board of Directors, he proposes to address these challenges with “continued, enhanced, and robust vigilance to support the work of the students, trainees, and young investigators of BMES. From reduced financial burdens to mentorship and expanded opportunities to share their work with the broader scientific community, our commitment to the next generation of biomaterial scientists and engineers is particularly needed at this critical juncture.”

Fisher currently serves as Past-President of the Americas Chapter of TERMIS and was the Co-Chair of the 2014 TERMIS-Americas Annual Meeting. In his TERMIS leadership roles, Fisher led efforts to broaden the TERMIS-Americas Chapter from North America to the entire Americas, established the Diversity, Equity, and Inclusion (DEI) Committee within the chapter, and participated in a delegation to South Africa to launch Africa’s first tissue engineering society.

In addition, Dr. Fisher currently serves as the Co-Editor-in-Chief of the journal Tissue Engineering while serving on the editorial boards of key biomedical engineering journals such as the Journal of Biomedical Materials Research Part ABioprintingBiofabrication; and the Journal of Tissue Engineering & Regenerative Medicine.

Story provided by the Fischell Department of Bioengineering.

University of Otago Collaboration Visit

S. McLoughlin and Dr. Jaydee Cabral

Shannon McLoughlin, a PhD Candidate in Professor John Fisher’s Tissue Engineering and Biomaterials Lab (TEBL), traveled to University of Otago in New Zealand to work with Associate Professor Jaydee Cabral on 3D printing nipple areolar complex (NAC) scaffolds for mastectomy patients. Dr. Cabral recently received a grant from the Royal Society of New Zealand Catalyst Fund for this collaborative work with Dr. Fisher’s lab. The proposal focuses on the use of 3D printing to generate vascularized NAC constructs and culturing them in 3D printed bioreactor systems. Shannon worked with an undergraduate honor’s student Emma Jackson on bioink synthesis, endothelial cell culture, and 3D bioprinting on the GeSIM Bioscaffolder. In addition to working in Dr. Cabral’s lab, she attended Queenstown Research Week Molecular Biology Meeting to present the lab’s work on “Biofabrication Strategies for the Generation of Bone Tissue Interfaces.” Outside of the lab, they explored Queenstown and Dunedin, learned about the rich history and culture of New Zealand, and even saw some penguins on the Peninsula!

S. McLoughlin and E. Jackson
bioprinting
S. McLoughlin presenting at the Queenstown Research
Week Molecular Biology Meeting

Story written by Shannon McLoughlin

2023 Fischell Fellowship in Biomedical Engineering

On Friday, August 25, more than 80 Fischell Department of Bioengineering graduate students, faculty, and staff celebrated at the University of Maryland Golf Course for the sixth annual EPIC Retreat where the 2023 Fischell Fellows were announced.

The Fischell Fellowship is a remarkable opportunity for graduate students pursuing research and product design within the biomedical industry. But what does it mean to be a Fischell Fellow? The Fellowship is given to individuals for recognition of their work and achievements and provides them with more than just the ability to fund their Ph.D. projects. This fellowship encourages recipients to submit invention disclosures for their research in order to push their scientific findings toward commercialization, enabling their discoveries to help people across the world.

This year, the Department announced the two recipients of the 2023 Fischell Fellowship in Biomedical Engineering as David Boegner and Shannon McLoughlin. Shannon is a fifth year PhD student conducting her research here in the Tissue Engineering and Biomaterials Laboratory. Her research involves enhancing extrusion bioprinting resolution to generate thin membranous tissue structures, such as the periosteum.


“I’m incredibly honored to be selected for this award and am extremely grateful to the Department for supporting me throughout my final year,”

“This fellowship has given me the opportunity to focus on the translational capacity of my research so that the promise of the technologies I’ve developed in the lab can become a clinical reality.”

Shannon McLoughlin